Drug interactions
Insulin aspart-insulin aspart protamine + Pasireotide
Severity: Moderate
Insulin aspart-insulin aspart protamine and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion, so insulin requirements often rise. Glucose control can change substantially in patients with diabetes.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism reduces insulin and incretin release, opposing insulin therapy.
What to do
Monitor blood glucose frequently, especially at initiation, and increase insulin or add antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Pasireotide?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion, so insulin requirements often rise. Glucose control can change substantially in patients with diabetes.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently, especially at initiation, and increase insulin or add antidiabetic therapy as needed.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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