Drug interactions
Insulin aspart protamine / insulin aspart + Insulin degludec-liraglutide
Severity: Major
Insulin aspart protamine / insulin aspart and Insulin degludec-liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination product already contains basal insulin, so adding premixed insulin aspart duplicates insulin therapy. Additive effects raise the risk of hypoglycemia.
What this interaction means in plain words
Insulin aspart protamine / insulin aspart and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive glucose-lowering effects from duplicate insulin therapy plus liraglutide.
What to do
Avoid concurrent use of multiple insulin regimens with this product unless deliberately planned. Reduce insulin doses and monitor glucose closely if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin aspart protamine / insulin aspart with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Insulin aspart protamine / insulin aspart and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The combination product already contains basal insulin, so adding premixed insulin aspart duplicates insulin therapy. Additive effects raise the risk of hypoglycemia.
How serious is the interaction between Insulin aspart protamine / insulin aspart and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of multiple insulin regimens with this product unless deliberately planned. Reduce insulin doses and monitor glucose closely if combined.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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