Drug interactions
Insulin degludec + Isoniazid
Severity: Minor
Insulin degludec and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can occasionally impair glucose control, which may reduce the effectiveness of insulin. Tuberculosis treatment in patients with diabetes often needs closer glycemic monitoring. The effect is unpredictable and usually small.
What this interaction means in plain words
Insulin degludec and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid may cause variable hyperglycemia, partly opposing insulin action; the mechanism is not well established.
What to do
Monitor blood glucose more frequently after starting isoniazid. Titrate the insulin degludec dose if glucose rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec and Isoniazid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Isoniazid
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Isoniazid?
MediHelp rates the interaction as minor. Insulin degludec and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can occasionally impair glucose control, which may reduce the effectiveness of insulin. Tuberculosis treatment in patients with diabetes often needs closer glycemic monitoring. The effect is unpredictable and usually small.
How serious is the interaction between Insulin degludec and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting isoniazid. Titrate the insulin degludec dose if glucose rises.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
