Drug interactions
Insulin degludec + Levonorgestrel intrauterine
Severity: Minor
Insulin degludec and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic exposure from an intrauterine levonorgestrel system is low, so any effect on glucose tolerance is small and unlikely to matter clinically.
What this interaction means in plain words
Insulin degludec and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible mild progestin-related insulin resistance, limited by low systemic hormone levels.
What to do
No dose change is needed routinely. Continue usual glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Insulin degludec and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic exposure from an intrauterine levonorgestrel system is low, so any effect on glucose tolerance is small and unlikely to matter clinically.
How serious is the interaction between Insulin degludec and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Continue usual glucose monitoring.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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