Drug interactions
Insulin degludec + Lonapegsomatropin
Severity: Moderate
Insulin degludec and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, particularly at higher doses, which can raise blood glucose. Patients with diabetes may need larger insulin doses.
What this interaction means in plain words
Insulin degludec and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and opposes insulin action.
What to do
Monitor blood glucose closely when starting or adjusting lonapegsomatropin. Increase insulin degludec as needed, and reduce it if growth hormone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Insulin degludec with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Insulin degludec and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, particularly at higher doses, which can raise blood glucose. Patients with diabetes may need larger insulin doses.
How serious is the interaction between Insulin degludec and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting lonapegsomatropin. Increase insulin degludec as needed, and reduce it if growth hormone is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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