Drug interactions
Insulin degludec + Magnesium salicylate
Severity: Moderate
Insulin degludec and Magnesium salicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose salicylates can lower blood glucose and may enhance the effect of insulin, leading to hypoglycemia. The effect is most relevant at anti-inflammatory doses.
What this interaction means in plain words
Insulin degludec and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates increase insulin secretion and peripheral glucose utilization, adding to insulin's effect.
What to do
Monitor blood glucose more often when high-dose salicylate is started or stopped and adjust the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Magnesium salicylate?
MediHelp rates the interaction as moderate. Insulin degludec and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose salicylates can lower blood glucose and may enhance the effect of insulin, leading to hypoglycemia. The effect is most relevant at anti-inflammatory doses.
How serious is the interaction between Insulin degludec and Magnesium salicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when high-dose salicylate is started or stopped and adjust the insulin dose accordingly.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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