Drug interactions
Insulin degludec + Methyclothiazide
Severity: Moderate
Insulin degludec and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause hyperglycemia and worsen glucose tolerance. Insulin degludec requirements may increase.
What this interaction means in plain words
Insulin degludec and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia impairs insulin secretion and may reduce insulin sensitivity.
What to do
Monitor glucose and serum potassium, and correct hypokalemia. Adjust the insulin degludec dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Methyclothiazide?
MediHelp rates the interaction as moderate. Insulin degludec and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause hyperglycemia and worsen glucose tolerance. Insulin degludec requirements may increase.
How serious is the interaction between Insulin degludec and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and serum potassium, and correct hypokalemia. Adjust the insulin degludec dose if control worsens.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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