Drug interactions
Insulin degludec + Olmesartan
Severity: Minor
Insulin degludec and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose lowering effect of insulin. This may increase the risk of hypoglycemia, mainly after starting or increasing the ARB.
What this interaction means in plain words
Insulin degludec and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin degludec belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade may improve insulin sensitivity, adding to the glucose lowering effect of insulin.
What to do
Monitor blood glucose when olmesartan is started or its dose changed, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Olmesartan?
MediHelp rates the interaction as minor. Insulin degludec and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose lowering effect of insulin. This may increase the risk of hypoglycemia, mainly after starting or increasing the ARB.
How serious is the interaction between Insulin degludec and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when olmesartan is started or its dose changed, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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