Drug interactions
Insulin degludec + Penbutolol
Severity: Moderate
Insulin degludec and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask the adrenergic warning signs of hypoglycemia and prolong recovery from it. They may also alter glycemic control in either direction.
What this interaction means in plain words
Insulin degludec and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade suppresses hypoglycemia symptoms and impairs glycogenolysis and counter-regulation.
What to do
Monitor blood glucose more closely and counsel the patient that tremor and tachycardia may be absent; sweating usually remains.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Penbutolol?
MediHelp rates the interaction as moderate. Insulin degludec and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask the adrenergic warning signs of hypoglycemia and prolong recovery from it. They may also alter glycemic control in either direction.
How serious is the interaction between Insulin degludec and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely and counsel the patient that tremor and tachycardia may be absent; sweating usually remains.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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