Drug interactions
Insulin degludec + Sacubitril / valsartan
Severity: Minor
Insulin degludec and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may slightly improve insulin sensitivity, and neprilysin inhibition has been linked to better glycemic control. Together with insulin this can increase the risk of hypoglycemia in some patients.
What this interaction means in plain words
Insulin degludec and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose lowering via improved insulin sensitivity. The mechanism is not firmly established.
What to do
Monitor blood glucose when starting sacubitril/valsartan. Lower the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Insulin degludec and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may slightly improve insulin sensitivity, and neprilysin inhibition has been linked to better glycemic control. Together with insulin this can increase the risk of hypoglycemia in some patients.
How serious is the interaction between Insulin degludec and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting sacubitril/valsartan. Lower the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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