Drug interactions
Insulin degludec + Sulfisoxazole
Severity: Moderate
Insulin degludec and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics have been associated with hypoglycemia, particularly in patients with renal impairment or on antidiabetic drugs. Used with insulin, they may increase the glucose-lowering effect.
What this interaction means in plain words
Insulin degludec and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering. Sulfonamides may stimulate insulin secretion, but the mechanism with exogenous insulin is not well defined.
What to do
Monitor blood glucose more closely during sulfisoxazole therapy. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec
Frequently asked questions
Can I take Insulin degludec with Sulfisoxazole?
MediHelp rates the interaction as moderate. Insulin degludec and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics have been associated with hypoglycemia, particularly in patients with renal impairment or on antidiabetic drugs. Used with insulin, they may increase the glucose-lowering effect.
How serious is the interaction between Insulin degludec and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely during sulfisoxazole therapy. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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