Drug interactions
Insulin degludec / insulin aspart + Insulin degludec-liraglutide
Severity: Major
Insulin degludec / insulin aspart and Insulin degludec-liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products contain insulin degludec, so using them together duplicates basal insulin. This markedly increases the risk of hypoglycemia.
What this interaction means in plain words
Insulin degludec / insulin aspart and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Therapeutic duplication of insulin degludec with additive glucose lowering, plus liraglutide effect.
What to do
Avoid using both products together; choose one regimen. If transitioning, adjust doses and monitor glucose closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Insulin degludec-liraglutide?
MediHelp rates the interaction as major. Insulin degludec / insulin aspart and Insulin degludec-liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both products contain insulin degludec, so using them together duplicates basal insulin. This markedly increases the risk of hypoglycemia.
How serious is the interaction between Insulin degludec / insulin aspart and Insulin degludec-liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both products together; choose one regimen. If transitioning, adjust doses and monitor glucose closely.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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