Drug interactions
Insulin degludec / insulin aspart + Isocarboxazid
Severity: Moderate
Insulin degludec / insulin aspart and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of insulin and may blunt recognition of hypoglycemia. Patients may experience more frequent or severe low blood glucose.
What this interaction means in plain words
Insulin degludec / insulin aspart and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibitors may increase insulin sensitivity and glucose utilization; the exact mechanism is not fully established.
What to do
Monitor blood glucose more frequently when isocarboxazid is started, changed or stopped, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Isocarboxazid?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of insulin and may blunt recognition of hypoglycemia. Patients may experience more frequent or severe low blood glucose.
How serious is the interaction between Insulin degludec / insulin aspart and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when isocarboxazid is started, changed or stopped, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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