Drug interactions
Insulin degludec / insulin aspart + Levonorgestrel
Severity: Minor
Insulin degludec / insulin aspart and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of insulin. With a low-dose intrauterine levonorgestrel system the systemic effect is small, so the change in insulin requirement is usually minor.
What this interaction means in plain words
Insulin degludec / insulin aspart and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism, as progestins may reduce insulin sensitivity.
What to do
Monitor blood glucose when starting or stopping levonorgestrel and adjust the insulin dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Levonorgestrel?
MediHelp rates the interaction as minor. Insulin degludec / insulin aspart and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance and may reduce the glucose-lowering effect of insulin. With a low-dose intrauterine levonorgestrel system the systemic effect is small, so the change in insulin requirement is usually minor.
How serious is the interaction between Insulin degludec / insulin aspart and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping levonorgestrel and adjust the insulin dose if control changes.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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