Drug interactions
Insulin degludec / insulin aspart + Lisinopril
Severity: Moderate
Insulin degludec / insulin aspart and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and have been linked to a greater risk of hypoglycemia in insulin-treated patients. The effect is typically modest but can be relevant when treatment is started.
What this interaction means in plain words
Insulin degludec / insulin aspart and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased insulin sensitivity with ACE inhibition adds to the glucose-lowering effect of insulin.
What to do
Monitor blood glucose more frequently after starting lisinopril and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Lisinopril?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and have been linked to a greater risk of hypoglycemia in insulin-treated patients. The effect is typically modest but can be relevant when treatment is started.
How serious is the interaction between Insulin degludec / insulin aspart and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently after starting lisinopril and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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