Drug interactions
Insulin degludec / insulin aspart + Metformin-repaglinide
Severity: Moderate
Insulin degludec / insulin aspart and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with metformin and repaglinide produces additive glucose lowering. This is often intentional but raises the risk of hypoglycemia, especially if doses are not adjusted. Repaglinide adds insulin-secretagogue effects on top of exogenous insulin.
What this interaction means in plain words
Insulin degludec / insulin aspart and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects through different pathways.
What to do
Monitor blood glucose frequently when combining or changing therapy, and reduce insulin or repaglinide doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with metformin and repaglinide produces additive glucose lowering. This is often intentional but raises the risk of hypoglycemia, especially if doses are not adjusted. Repaglinide adds insulin-secretagogue effects on top of exogenous insulin.
How serious is the interaction between Insulin degludec / insulin aspart and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when combining or changing therapy, and reduce insulin or repaglinide doses if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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