Drug interactions
Insulin degludec / insulin aspart + Ramipril
Severity: Moderate
Insulin degludec / insulin aspart and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can increase insulin sensitivity and enhance the glucose-lowering effect of insulin. This can result in hypoglycemia, especially after ramipril is started or the dose is increased.
What this interaction means in plain words
Insulin degludec / insulin aspart and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition improves insulin sensitivity, producing additive blood glucose lowering.
What to do
Monitor blood glucose more frequently when ramipril is started or titrated, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Ramipril?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can increase insulin sensitivity and enhance the glucose-lowering effect of insulin. This can result in hypoglycemia, especially after ramipril is started or the dose is increased.
How serious is the interaction between Insulin degludec / insulin aspart and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when ramipril is started or titrated, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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