Drug interactions
Insulin degludec / insulin aspart + Sacubitril-valsartan
Severity: Moderate
Insulin degludec / insulin aspart and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and so increase the glucose-lowering effect of insulin. This can occasionally lead to hypoglycemia, particularly when therapy is started.
What this interaction means in plain words
Insulin degludec / insulin aspart and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Improved insulin sensitivity with angiotensin receptor blockade adds to the pharmacodynamic effect of insulin.
What to do
Monitor blood glucose more frequently when starting or adjusting sacubitril-valsartan, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers may enhance insulin sensitivity and so increase the glucose-lowering effect of insulin. This can occasionally lead to hypoglycemia, particularly when therapy is started.
How serious is the interaction between Insulin degludec / insulin aspart and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or adjusting sacubitril-valsartan, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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