Drug interactions
Insulin degludec / insulin aspart + Trandolapril
Severity: Moderate
Insulin degludec / insulin aspart and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin. This can lead to hypoglycemia, particularly after starting the ACE inhibitor or in patients with variable glucose control.
What this interaction means in plain words
Insulin degludec / insulin aspart and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition enhances insulin sensitivity, producing an additive glucose-lowering effect.
What to do
Monitor blood glucose more often when trandolapril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Trandolapril?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may increase the glucose-lowering effect of insulin. This can lead to hypoglycemia, particularly after starting the ACE inhibitor or in patients with variable glucose control.
How serious is the interaction between Insulin degludec / insulin aspart and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when trandolapril is started or the dose changed. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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