Drug interactions
Insulin degludec / insulin aspart + Valsartan
Severity: Minor
Insulin degludec / insulin aspart and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can slightly improve insulin sensitivity, which may increase the glucose lowering effect of insulin. This can occasionally lead to hypoglycemia, particularly when treatment is started or doses are increased.
What this interaction means in plain words
Insulin degludec / insulin aspart and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Improved insulin sensitivity with angiotensin receptor blockade producing additive glucose lowering.
What to do
Monitor blood glucose more frequently when valsartan is started or changed, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Valsartan?
MediHelp rates the interaction as minor. Insulin degludec / insulin aspart and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers can slightly improve insulin sensitivity, which may increase the glucose lowering effect of insulin. This can occasionally lead to hypoglycemia, particularly when treatment is started or doses are increased.
How serious is the interaction between Insulin degludec / insulin aspart and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when valsartan is started or changed, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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