Drug interactions
Insulin degludec / insulin aspart + Vitamin b3
Severity: Moderate
Insulin degludec / insulin aspart and Vitamin b3: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin at lipid-lowering doses can raise blood glucose and reduce insulin sensitivity. In patients using insulin this may lead to poorer glycemic control and higher insulin requirements.
What this interaction means in plain words
Insulin degludec / insulin aspart and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Niacin induces insulin resistance and impairs glucose tolerance, opposing the glucose-lowering effect of insulin.
What to do
Monitor blood glucose more frequently when niacin is started, changed or stopped. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin b3
- Lovastatin + Vitamin b3 Major
- Simvastatin + Vitamin b3 Major
- Atorvastatin + Vitamin b3 Moderate
- Cholestyramine + Vitamin b3 Moderate
- Colestipol + Vitamin b3 Moderate
- Fluvastatin + Vitamin b3 Moderate
Frequently asked questions
Can I take Insulin degludec / insulin aspart with Vitamin b3?
MediHelp rates the interaction as moderate. Insulin degludec / insulin aspart and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin at lipid-lowering doses can raise blood glucose and reduce insulin sensitivity. In patients using insulin this may lead to poorer glycemic control and higher insulin requirements.
How serious is the interaction between Insulin degludec / insulin aspart and Vitamin b3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when niacin is started, changed or stopped. Adjust the insulin dose as needed.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Atorvastatin. The full list is on the Vitamin b3 page.
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