Drug interactions
Insulin degludec-liraglutide + Insulin lispro protamine / insulin lispro
Severity: Major
Insulin degludec-liraglutide and Insulin lispro protamine / insulin lispro: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Premixed lispro insulin duplicates the insulin in the combination product. Additive effects with liraglutide raise hypoglycemia risk.
What this interaction means in plain words
Insulin degludec-liraglutide and Insulin lispro protamine / insulin lispro can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive glucose-lowering effects from duplicate insulin therapy.
What to do
Avoid concurrent use of separate insulin regimens with this product. If combined, reduce doses and monitor glucose closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Insulin lispro protamine / insulin lispro can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Premixed lispro insulin duplicates the insulin in the combination product. Additive effects with liraglutide raise hypoglycemia risk.
How serious is the interaction between Insulin degludec-liraglutide and Insulin lispro protamine / insulin lispro?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of separate insulin regimens with this product. If combined, reduce doses and monitor glucose closely.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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