Drug interactions
Insulin degludec-liraglutide + Insulin lispro
Severity: Moderate
Insulin degludec-liraglutide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The fixed-dose combination already contains basal insulin and a GLP-1 agonist, so adding a mealtime insulin increases the total glucose-lowering effect. This raises the chance of hypoglycemia, particularly if the mealtime insulin dose is not reduced when the combination is started.
What this interaction means in plain words
Insulin degludec-liraglutide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from insulin and GLP-1 receptor agonism.
What to do
Monitor blood glucose closely when starting or adjusting the combination and reduce the lispro dose if hypoglycemia occurs. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Insulin lispro
Frequently asked questions
Can I take Insulin degludec-liraglutide with Insulin lispro?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The fixed-dose combination already contains basal insulin and a GLP-1 agonist, so adding a mealtime insulin increases the total glucose-lowering effect. This raises the chance of hypoglycemia, particularly if the mealtime insulin dose is not reduced when the combination is started.
How serious is the interaction between Insulin degludec-liraglutide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting the combination and reduce the lispro dose if hypoglycemia occurs. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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