Drug interactions
Insulin degludec-liraglutide + Insulin regular human
Severity: Moderate
Insulin degludec-liraglutide and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular human insulin used with the basal insulin and GLP-1 agonist product has additive glucose-lowering effects. Hypoglycemia can occur if mealtime insulin is not reduced.
What this interaction means in plain words
Insulin degludec-liraglutide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects of insulin and GLP-1 receptor agonism.
What to do
Monitor glucose closely and reduce the regular insulin dose when starting the combination. Titrate to glycemic targets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Insulin regular human?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular human insulin used with the basal insulin and GLP-1 agonist product has additive glucose-lowering effects. Hypoglycemia can occur if mealtime insulin is not reduced.
How serious is the interaction between Insulin degludec-liraglutide and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the regular insulin dose when starting the combination. Titrate to glycemic targets.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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