Drug interactions
Insulin degludec-liraglutide + Liotrix
Severity: Moderate
Insulin degludec-liraglutide and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains levothyroxine and liothyronine, which increase glucose turnover and may raise insulin requirements. Glycemic control may worsen as thyroid replacement is started or increased.
What this interaction means in plain words
Insulin degludec-liraglutide and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase hepatic gluconeogenesis, glycogenolysis and glucose turnover, opposing antidiabetic therapy.
What to do
Monitor glucose when starting or adjusting liotrix. Adjust antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Liotrix?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains levothyroxine and liothyronine, which increase glucose turnover and may raise insulin requirements. Glycemic control may worsen as thyroid replacement is started or increased.
How serious is the interaction between Insulin degludec-liraglutide and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or adjusting liotrix. Adjust antidiabetic doses as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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