Drug interactions
Insulin degludec-liraglutide + Lithium
Severity: Moderate
Insulin degludec-liraglutide and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lithium can alter glucose homeostasis in either direction, causing hypoglycemia or hyperglycemia in some patients. This may make glycemic control less predictable in people using insulin degludec and liraglutide.
What this interaction means in plain words
Insulin degludec-liraglutide and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Lithium affects insulin secretion and glucose metabolism variably; the mechanism is not fully defined.
What to do
Monitor blood glucose more frequently when lithium is started, changed or stopped and adjust insulin dosing as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Lithium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Insulin degludec-liraglutide with Lithium?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lithium can alter glucose homeostasis in either direction, causing hypoglycemia or hyperglycemia in some patients. This may make glycemic control less predictable in people using insulin degludec and liraglutide.
How serious is the interaction between Insulin degludec-liraglutide and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when lithium is started, changed or stopped and adjust insulin dosing as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
