Drug interactions
Insulin degludec-liraglutide + Mestranol
Severity: Minor
Insulin degludec-liraglutide and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mestranol, an estrogen in some oral contraceptives, can impair glucose tolerance. This may reduce the glucose-lowering effect of insulin degludec/liraglutide.
What this interaction means in plain words
Insulin degludec-liraglutide and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through estrogen-related reduction in glucose tolerance.
What to do
Monitor glucose when starting or stopping mestranol. Adjust the antidiabetic dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Mestranol?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mestranol, an estrogen in some oral contraceptives, can impair glucose tolerance. This may reduce the glucose-lowering effect of insulin degludec/liraglutide.
How serious is the interaction between Insulin degludec-liraglutide and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping mestranol. Adjust the antidiabetic dose if control changes.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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