Drug interactions
Insulin degludec-liraglutide + Metoclopramide intranasal
Severity: Minor
Insulin degludec-liraglutide and Metoclopramide intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide speeds gastric emptying, so nutrients reach the small intestine and are absorbed faster. This can change postprandial glucose and the timing of glucose excursions relative to insulin action. Liraglutide slows gastric emptying, so the two drugs have opposing effects on gastric motility.
What this interaction means in plain words
Insulin degludec-liraglutide and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Prokinetic enhancement of gastric emptying alters the rate of nutrient absorption and postprandial glucose, opposing the GLP-1 agonist's delay of emptying.
What to do
Monitor blood glucose, especially after meals, when metoclopramide is started or stopped. Adjust the insulin dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Metoclopramide intranasal?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Metoclopramide intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide speeds gastric emptying, so nutrients reach the small intestine and are absorbed faster. This can change postprandial glucose and the timing of glucose excursions relative to insulin action. Liraglutide slows gastric emptying, so the two drugs have opposing effects on gastric motility.
How serious is the interaction between Insulin degludec-liraglutide and Metoclopramide intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, especially after meals, when metoclopramide is started or stopped. Adjust the insulin dose if control changes.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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