Drug interactions
Insulin degludec-liraglutide + Octreotide
Severity: Moderate
Insulin degludec-liraglutide and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia. Glucose control with insulin and liraglutide may become unpredictable.
What this interaction means in plain words
Insulin degludec-liraglutide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin analog alters pancreatic hormone secretion, changing glucose levels and insulin requirements.
What to do
Monitor glucose frequently when octreotide is started or adjusted and change the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-liraglutide and Octreotide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin degludec-liraglutide
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Octreotide?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia. Glucose control with insulin and liraglutide may become unpredictable.
How serious is the interaction between Insulin degludec-liraglutide and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when octreotide is started or adjusted and change the insulin dose as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
