Drug interactions
Insulin degludec-liraglutide + Olanzapine
Severity: Moderate
Insulin degludec-liraglutide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can counteract insulin degludec and liraglutide. Diabetic control may deteriorate and require treatment adjustment.
What this interaction means in plain words
Insulin degludec-liraglutide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin degludec-liraglutide belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Antipsychotic-induced insulin resistance and impaired insulin secretion oppose antidiabetic effect.
What to do
Monitor glucose and HbA1c regularly during olanzapine therapy and increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Olanzapine
Frequently asked questions
Can I take Insulin degludec-liraglutide with Olanzapine?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can counteract insulin degludec and liraglutide. Diabetic control may deteriorate and require treatment adjustment.
How serious is the interaction between Insulin degludec-liraglutide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly during olanzapine therapy and increase antidiabetic therapy as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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