Drug interactions
Insulin degludec-liraglutide + Progesterone intravaginal
Severity: Minor
Insulin degludec-liraglutide and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins can modestly impair glucose tolerance, but vaginal progesterone has limited systemic exposure. Any effect on insulin degludec/liraglutide is expected to be small.
What this interaction means in plain words
Insulin degludec-liraglutide and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestogens may reduce insulin sensitivity, mildly opposing antidiabetic therapy.
What to do
Monitor blood glucose routinely when starting or stopping progesterone. Adjust the insulin dose only if glucose control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Progesterone intravaginal?
MediHelp rates the interaction as minor. Insulin degludec-liraglutide and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins can modestly impair glucose tolerance, but vaginal progesterone has limited systemic exposure. Any effect on insulin degludec/liraglutide is expected to be small.
How serious is the interaction between Insulin degludec-liraglutide and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose routinely when starting or stopping progesterone. Adjust the insulin dose only if glucose control changes.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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