Drug interactions
Insulin degludec-liraglutide + Salsalate
Severity: Moderate
Insulin degludec-liraglutide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate that can lower blood glucose at higher doses, which may enhance insulin action and cause hypoglycemia in patients on insulin degludec with liraglutide.
What this interaction means in plain words
Insulin degludec-liraglutide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates improve insulin secretion and glucose utilization, which adds to insulin glucose-lowering effects.
What to do
Monitor blood glucose more often when salsalate is started or the dose is raised, and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Salsalate?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate that can lower blood glucose at higher doses, which may enhance insulin action and cause hypoglycemia in patients on insulin degludec with liraglutide.
How serious is the interaction between Insulin degludec-liraglutide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when salsalate is started or the dose is raised, and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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