Drug interactions
Insulin degludec-liraglutide + Thyroid desiccated
Severity: Moderate
Insulin degludec-liraglutide and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases glucose production and metabolic rate, which can raise blood glucose and increase insulin requirements. Starting or increasing thyroid replacement may weaken glycemic control on insulin degludec/liraglutide.
What this interaction means in plain words
Insulin degludec-liraglutide and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase gluconeogenesis, glycogenolysis and glucose absorption, opposing antidiabetic therapy.
What to do
Monitor blood glucose when thyroid therapy is started or adjusted. Increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Insulin degludec-liraglutide with Thyroid desiccated?
MediHelp rates the interaction as moderate. Insulin degludec-liraglutide and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases glucose production and metabolic rate, which can raise blood glucose and increase insulin requirements. Starting or increasing thyroid replacement may weaken glycemic control on insulin degludec/liraglutide.
How serious is the interaction between Insulin degludec-liraglutide and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when thyroid therapy is started or adjusted. Increase the insulin dose as needed.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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