Drug interactions
Insulin detemir + Nateglinide
Severity: Moderate
Insulin detemir and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide with insulin gives additive glucose lowering and a risk of hypoglycemia. The combination is generally not recommended as both lower glucose by raising insulin levels.
What this interaction means in plain words
Insulin detemir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive effect of meglitinide-stimulated insulin secretion and exogenous insulin.
What to do
Monitor blood glucose closely and reduce the insulin or nateglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin detemir with Nateglinide?
MediHelp rates the interaction as moderate. Insulin detemir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide with insulin gives additive glucose lowering and a risk of hypoglycemia. The combination is generally not recommended as both lower glucose by raising insulin levels.
How serious is the interaction between Insulin detemir and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the insulin or nateglinide dose if hypoglycemia occurs.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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