Drug interactions
Insulin detemir + Nelfinavir
Severity: Moderate
Insulin detemir and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir, like other HIV protease inhibitors, may cause insulin resistance and hyperglycemia. This can reduce the effectiveness of insulin detemir and raise insulin requirements.
What this interaction means in plain words
Insulin detemir and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitors induce insulin resistance and impair peripheral glucose uptake.
What to do
Check blood glucose frequently after starting nelfinavir and increase the insulin detemir dose as required. Re-evaluate when the antiretroviral is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin detemir and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin detemir
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Insulin detemir with Nelfinavir?
MediHelp rates the interaction as moderate. Insulin detemir and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir, like other HIV protease inhibitors, may cause insulin resistance and hyperglycemia. This can reduce the effectiveness of insulin detemir and raise insulin requirements.
How serious is the interaction between Insulin detemir and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently after starting nelfinavir and increase the insulin detemir dose as required. Re-evaluate when the antiretroviral is changed.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
