Drug interactions
Insulin detemir + Pasireotide
Severity: Moderate
Insulin detemir and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide suppresses insulin and incretin secretion and frequently causes hyperglycemia, so insulin requirements may rise. Glucose may also fluctuate as treatment changes.
What this interaction means in plain words
Insulin detemir and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor activation reduces endogenous insulin, GLP-1 and GIP secretion, opposing glycemic control.
What to do
Monitor glucose before and during pasireotide therapy and increase insulin detemir as needed. Reduce the insulin dose again if pasireotide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin detemir with Pasireotide?
MediHelp rates the interaction as moderate. Insulin detemir and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide suppresses insulin and incretin secretion and frequently causes hyperglycemia, so insulin requirements may rise. Glucose may also fluctuate as treatment changes.
How serious is the interaction between Insulin detemir and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose before and during pasireotide therapy and increase insulin detemir as needed. Reduce the insulin dose again if pasireotide is stopped.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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