Drug interactions
Insulin detemir + Somatrogon
Severity: Moderate
Insulin detemir and Somatrogon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatrogon, a growth hormone analog, can reduce insulin sensitivity and raise blood glucose, so insulin doses may need to rise. Glycemic control can worsen in patients with diabetes.
What this interaction means in plain words
Insulin detemir and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin detemir belongs to Endocrine; Somatrogon belongs to Endocrine.
Why it happens
Growth hormone antagonizes insulin action by promoting lipolysis and hepatic glucose output and by reducing peripheral insulin sensitivity.
What to do
Monitor blood glucose when somatrogon is started or the dose is changed, and adjust the insulin detemir dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Other interactions of Somatrogon
- Alogliptin-metformin + Somatrogon Moderate
- Alogliptin-pioglitazone + Somatrogon Moderate
- Alogliptin + Somatrogon Moderate
- Canagliflozin-metformin + Somatrogon Moderate
- Chlorpropamide + Somatrogon Moderate
- Cyclosporin + Somatrogon Moderate
Frequently asked questions
Can I take Insulin detemir with Somatrogon?
MediHelp rates the interaction as moderate. Insulin detemir and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatrogon, a growth hormone analog, can reduce insulin sensitivity and raise blood glucose, so insulin doses may need to rise. Glycemic control can worsen in patients with diabetes.
How serious is the interaction between Insulin detemir and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when somatrogon is started or the dose is changed, and adjust the insulin detemir dose accordingly.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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