Drug interactions
Insulin glargine-lixisenatide + Isoniazid
Severity: Minor
Insulin glargine-lixisenatide and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose control and has been reported to cause hyperglycemia in some patients, which may reduce the effect of antidiabetic therapy. The effect is inconsistent and the evidence is limited.
What this interaction means in plain words
Insulin glargine-lixisenatide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
The mechanism is not clearly established; altered carbohydrate metabolism is suspected.
What to do
Monitor blood glucose when isoniazid is started or stopped and adjust the antidiabetic dose if glycemic control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Isoniazid
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Isoniazid?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glucose control and has been reported to cause hyperglycemia in some patients, which may reduce the effect of antidiabetic therapy. The effect is inconsistent and the evidence is limited.
How serious is the interaction between Insulin glargine-lixisenatide and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when isoniazid is started or stopped and adjust the antidiabetic dose if glycemic control worsens.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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