Drug interactions
Insulin glargine-lixisenatide + Lonapegsomatropin
Severity: Moderate
Insulin glargine-lixisenatide and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity, especially at higher doses, and can raise blood glucose. Patients with diabetes may need higher doses of insulin or other antidiabetic drugs.
What this interaction means in plain words
Insulin glargine-lixisenatide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through growth hormone-induced insulin resistance.
What to do
Monitor blood glucose when starting or adjusting the growth hormone dose and increase antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity, especially at higher doses, and can raise blood glucose. Patients with diabetes may need higher doses of insulin or other antidiabetic drugs.
How serious is the interaction between Insulin glargine-lixisenatide and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting the growth hormone dose and increase antidiabetic therapy as needed.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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