Drug interactions
Insulin glargine-lixisenatide + Octreotide
Severity: Moderate
Insulin glargine-lixisenatide and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone, so it can cause either hypoglycemia or hyperglycemia in diabetic patients. Insulin requirements may change unpredictably.
What this interaction means in plain words
Insulin glargine-lixisenatide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin analog inhibits secretion of insulin, glucagon and counter-regulatory hormones, altering glycemic balance.
What to do
Monitor blood glucose frequently when starting, changing or stopping octreotide and adjust insulin accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Octreotide?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone, so it can cause either hypoglycemia or hyperglycemia in diabetic patients. Insulin requirements may change unpredictably.
How serious is the interaction between Insulin glargine-lixisenatide and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, changing or stopping octreotide and adjust insulin accordingly.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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