Drug interactions
Insulin glargine-lixisenatide + Olanzapine
Severity: Moderate
Insulin glargine-lixisenatide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause weight gain, insulin resistance and hyperglycemia, which can counteract the glucose-lowering effect of insulin glargine and lixisenatide. Glycemic control may worsen and diabetes treatment requirements may rise after olanzapine is started.
What this interaction means in plain words
Insulin glargine-lixisenatide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism: olanzapine induces insulin resistance and metabolic disturbance, opposing the antidiabetic effect.
What to do
Monitor fasting and postprandial glucose and HbA1c when olanzapine is started or changed. Titrate the insulin glargine component as needed, and consider a less metabolically active antipsychotic if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Olanzapine?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause weight gain, insulin resistance and hyperglycemia, which can counteract the glucose-lowering effect of insulin glargine and lixisenatide. Glycemic control may worsen and diabetes treatment requirements may rise after olanzapine is started.
How serious is the interaction between Insulin glargine-lixisenatide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting and postprandial glucose and HbA1c when olanzapine is started or changed. Titrate the insulin glargine component as needed, and consider a less metabolically active antipsychotic if control deteriorates.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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