Drug interactions
Insulin glargine-lixisenatide + Olmesartan
Severity: Minor
Insulin glargine-lixisenatide and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally leading to hypoglycemia. The effect is generally modest but may be noticed after starting the ARB.
What this interaction means in plain words
Insulin glargine-lixisenatide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin glargine-lixisenatide belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Probable pharmacodynamic effect of improved insulin sensitivity with angiotensin receptor blockade; the mechanism is not fully established.
What to do
Check blood glucose more often when olmesartan is started and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on recognizing hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Olmesartan?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may improve insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally leading to hypoglycemia. The effect is generally modest but may be noticed after starting the ARB.
How serious is the interaction between Insulin glargine-lixisenatide and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often when olmesartan is started and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on recognizing hypoglycemia symptoms.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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