Drug interactions
Insulin glargine-lixisenatide + Pindolol
Severity: Moderate
Insulin glargine-lixisenatide and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can mask the adrenergic warning signs of hypoglycemia and delay recovery. Pindolol has intrinsic sympathomimetic activity and may have less effect, but caution still applies.
What this interaction means in plain words
Insulin glargine-lixisenatide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade blunts hypoglycemia symptoms and counter-regulatory glucose recovery.
What to do
Counsel patients that sweating may be the main warning sign and monitor glucose regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Pindolol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can mask the adrenergic warning signs of hypoglycemia and delay recovery. Pindolol has intrinsic sympathomimetic activity and may have less effect, but caution still applies.
How serious is the interaction between Insulin glargine-lixisenatide and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients that sweating may be the main warning sign and monitor glucose regularly.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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