Drug interactions
Insulin glargine-lixisenatide + Salsalate
Severity: Moderate
Insulin glargine-lixisenatide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is metabolized to salicylate, which can enhance the glucose-lowering effect of insulin and raise the risk of hypoglycemia.
What this interaction means in plain words
Insulin glargine-lixisenatide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates increase insulin secretion and peripheral glucose utilization, adding to insulin's effect.
What to do
Monitor glucose more often when salsalate is started or titrated and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Salsalate?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is metabolized to salicylate, which can enhance the glucose-lowering effect of insulin and raise the risk of hypoglycemia.
How serious is the interaction between Insulin glargine-lixisenatide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more often when salsalate is started or titrated and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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