Drug interactions
Insulin glargine-lixisenatide + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Insulin glargine-lixisenatide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin drives potassium into cells, while bowel preparations cause fluid and electrolyte losses, so hypokalemia is possible. Reduced food intake during bowel preparation also raises hypoglycemia risk, and lixisenatide may add to nausea and dehydration.
What this interaction means in plain words
Insulin glargine-lixisenatide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Insulin shifts potassium intracellularly, adding to electrolyte losses and reduced oral intake from bowel preparation.
What to do
Adjust insulin dosing for the fasting and preparation period, and monitor glucose and electrolytes, especially in patients with renal impairment or on other potassium-lowering drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin drives potassium into cells, while bowel preparations cause fluid and electrolyte losses, so hypokalemia is possible. Reduced food intake during bowel preparation also raises hypoglycemia risk, and lixisenatide may add to nausea and dehydration.
How serious is the interaction between Insulin glargine-lixisenatide and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust insulin dosing for the fasting and preparation period, and monitor glucose and electrolytes, especially in patients with renal impairment or on other potassium-lowering drugs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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