Drug interactions
Insulin glargine-lixisenatide + Somatropin
Severity: Moderate
Insulin glargine-lixisenatide and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin reduces insulin sensitivity and can raise blood glucose, so antidiabetic requirements may increase after starting growth hormone.
What this interaction means in plain words
Insulin glargine-lixisenatide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glargine-lixisenatide belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases hepatic glucose output, opposing insulin action.
What to do
Monitor glucose closely after starting or changing somatropin and adjust the insulin dose as needed. Reduce doses if growth hormone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Somatropin?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin reduces insulin sensitivity and can raise blood glucose, so antidiabetic requirements may increase after starting growth hormone.
How serious is the interaction between Insulin glargine-lixisenatide and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely after starting or changing somatropin and adjust the insulin dose as needed. Reduce doses if growth hormone is stopped.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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