Drug interactions
Insulin glargine-lixisenatide + Sulfadiazine
Severity: Moderate
Insulin glargine-lixisenatide and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can enhance the glucose-lowering effect of insulin and may cause hypoglycemia. The effect is most relevant in patients with renal impairment or poor oral intake.
What this interaction means in plain words
Insulin glargine-lixisenatide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion and add to the glucose-lowering effect; the mechanism is not fully established.
What to do
Monitor blood glucose more often when starting or stopping the sulfonamide. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Sulfadiazine?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can enhance the glucose-lowering effect of insulin and may cause hypoglycemia. The effect is most relevant in patients with renal impairment or poor oral intake.
How serious is the interaction between Insulin glargine-lixisenatide and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when starting or stopping the sulfonamide. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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