Drug interactions
Insulin glargine-lixisenatide + Sulfasalazine
Severity: Minor
Insulin glargine-lixisenatide and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine releases salicylate-related metabolites, and sulfonamide-type drugs have occasionally been linked to hypoglycemia. A small additive glucose-lowering effect with insulin is possible, though rarely significant.
What this interaction means in plain words
Insulin glargine-lixisenatide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hypoglycemic effect via salicylate and sulfonamide components; not well characterized.
What to do
Monitor blood glucose when sulfasalazine is started at higher doses and reduce insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Sulfasalazine?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine releases salicylate-related metabolites, and sulfonamide-type drugs have occasionally been linked to hypoglycemia. A small additive glucose-lowering effect with insulin is possible, though rarely significant.
How serious is the interaction between Insulin glargine-lixisenatide and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulfasalazine is started at higher doses and reduce insulin if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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