Drug interactions
Insulin glargine-lixisenatide + Willow bark
Severity: Minor
Insulin glargine-lixisenatide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylate, and large doses might add to the glucose-lowering effect of insulin. Typical doses give low salicylate exposure, so the effect is likely small.
What this interaction means in plain words
Insulin glargine-lixisenatide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate-derived improvement in insulin sensitivity at high exposure.
What to do
Monitor blood glucose if large amounts of willow bark are taken and reduce insulin if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Willow bark?
MediHelp rates the interaction as minor. Insulin glargine-lixisenatide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylate, and large doses might add to the glucose-lowering effect of insulin. Typical doses give low salicylate exposure, so the effect is likely small.
How serious is the interaction between Insulin glargine-lixisenatide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if large amounts of willow bark are taken and reduce insulin if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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