Drug interactions
Insulin glargine-lixisenatide + Xipamide
Severity: Moderate
Insulin glargine-lixisenatide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can impair glucose tolerance and raise blood glucose, weakening the effect of insulin. The effect is usually modest but can be significant in poorly controlled diabetes.
What this interaction means in plain words
Insulin glargine-lixisenatide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-related potassium depletion and reduced insulin sensitivity impair glucose handling; insulin clearance is not meaningfully increased.
What to do
Monitor blood glucose and potassium when starting or adjusting xipamide. Adjust the antidiabetic dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Xipamide?
MediHelp rates the interaction as moderate. Insulin glargine-lixisenatide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics such as xipamide can impair glucose tolerance and raise blood glucose, weakening the effect of insulin. The effect is usually modest but can be significant in poorly controlled diabetes.
How serious is the interaction between Insulin glargine-lixisenatide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium when starting or adjusting xipamide. Adjust the antidiabetic dose if control worsens.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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